Resource Type

Journal Article 858

Conference Videos 53

Conference Information 1

Year

2024 5

2023 112

2022 155

2021 162

2020 85

2019 48

2018 28

2017 29

2016 41

2015 27

2014 19

2013 24

2012 25

2011 16

2010 16

2009 32

2008 26

2007 29

2006 2

2005 2

open ︾

Keywords

1 15

Deep learning 7

acute myeloid leukemia 7

immunotherapy 7

2 6

Reinforcement learning 5

prognosis 5

PD-L1 4

drug resistance 4

hepatocellular carcinoma 4

leukemia 4

pig 4

1) 3

Multi-agent system 3

apoptosis 3

cancer immunotherapy 3

degradation 3

invasion 3

mesenchymal stem cells 3

open ︾

Search scope:

排序： Display mode:

Soluble triggering receptor expressed on myeloid cell-1 (sTREM-1): a potential biomarker for the diagnosis

Changlin Cao, Jingxian Gu, Jingyao Zhang

Frontiers of Medicine 2017, Volume 11, Issue 2,   Pages 169-177 doi: 10.1007/s11684-017-0505-z

Abstract: An example of these biomarkers is triggering receptor expressed on myeloid cell-1 (TREM-1), which isa cell surface receptor expressed on monocytes/macrophages and neutrophils.TREM-1 amplifies inflammation by activating the TREM-1/DAP12 pathway.Soluble TREM-1 (sTREM-1) is a special form of TREM-1 that can be directly tested in human body fluidsand well-known biomarker for infectious diseases. sTREM-1 level can be potentially used for the early

Keywords： soluble triggering receptor expressed on myeloid cells-1     infectious diseases     diagnosis and prognosis    

HTML PDF Collect

4-1BBL expressed by eukaryotic cells activates immune cells and suppresses the progression of murine

Hui QIU, Hui ZHANG, Zuohua FENG

Frontiers of Medicine 2009, Volume 3, Issue 1,   Pages 20-25 doi: 10.1007/s11684-009-0006-9

Abstract: The function of 4-1BB/4-1BBL expressed by the immune cells has been the focus for many tumor immunotherapyIn this study, 4-1BBL was expressed in non-immune cells and non-tumor cells, and the role of 4-1BBL inThe study demonstrated that the molecule 4-1BBL expressed by BHK cells could enhance the proliferationThe treatment with plasmid p4-1BBL revealed that the number of CD8 T cells in the peri-tumoral tissueThese findings suggest that expression of 4-1BBL by normal cells in the tumor microenvironment can enhance

Keywords： 4-1BB ligand     tumor immunotherapy     tumor microenvironment    

HTML PDF Collect

Chimeric antigen receptor T cell therapies for acute myeloid leukemia

Bin Gu, Jianhong Chu, Depei Wu

Frontiers of Medicine 2020, Volume 14, Issue 6,   Pages 701-710 doi: 10.1007/s11684-020-0763-z

Abstract: Abstract Chimeric antigen receptor T cell (CAR T) therapies have achieved unprecedented efficacy in B-cellAcute myeloid leukemia (AML) is a group of heterogeneous myeloid malignancies.

Keywords： acute myeloid leukemia     CAR T     immunotherapy    

HTML PDF Collect

Plasma soluble C-type lectin-like receptor-2 is associated with the risk of coronary artery disease

Min Fei, Li Xiang, Xichen Chai, Jingchun Jin, Tao You, Yiming Zhao, Changgeng Ruan, Yiwen Hao, Li Zhu

Frontiers of Medicine 2020, Volume 14, Issue 1,   Pages 81-90 doi: 10.1007/s11684-019-0692-x

Abstract: Accumulating evidence suggests that C-type lectin-like receptor-2 (CLEC-2) plays an important role inPlasma levels of soluble CLEC-2 (sCLEC-2) were measured using the enzyme-linked immunosorbent assay (multivariate adjusted odds ratios (95% confidence interval) of CAD reached 2.01 (1.52–2.66) ( <0.001) for each 1-

Keywords： soluble C-type lectin-like receptor-2     coronary artery disease     risk factor    

HTML PDF Collect

Alternative splicing of inner-ear-expressed genes

Yanfei Wang,Yueyue Liu,Hongyun Nie,Xin Ma,Zhigang Xu

Frontiers of Medicine 2016, Volume 10, Issue 3,   Pages 250-257 doi: 10.1007/s11684-016-0454-y

Abstract: subject to inner-ear-specific alternative splicing, and as a result, Cdh23(+68) is only expressedin inner ear hair cells.Differential splicing of Kcnma1, which encodes for the α subunit of the Ca2+

Keywords： alternative splicing     inner ear     hearing loss     hair cells    

HTML PDF Collect

Recent advances in myeloid-derived suppressor cell biology

Mahmoud Mohammad Yaseen, Nizar Mohammad Abuharfeil, Homa Darmani, Ammar Daoud

Frontiers of Medicine 2021, Volume 15, Issue 2,   Pages 232-251 doi: 10.1007/s11684-020-0797-2

Abstract: In recent years, studying the role of myeloid-derived suppressor cells (MDSCs) in many pathological inflammatoryThe following topics will be specifically focused upon: (1) definition and characterization of MDSCs;(2) whether all MDSC populations consist of immature cells; (3) technical issues in MDSC isolation,

Keywords： non-human primates (rhesus macaques)     myeloid-derived pro-inflammatory cells (MDPCs)     autoimmune disorders    

HTML PDF Collect

Influence of β-elemene on the secretion of angiotensin II and expression of AT1R in hepatic stellatecells

Ling YANG, Rui ZHU, Qingjing ZHU, Dan DAN, Jin YE, Keshu XU, Xiaohua HOU

Frontiers of Medicine 2009, Volume 3, Issue 1,   Pages 36-40 doi: 10.1007/s11684-009-0020-y

Abstract: influence of β-elemene on the secretion of angiotensin II (ANG II) and the expression of angiotensin receptortype 1 (AT1R) in hepatic stellate cells (HSCs)The protein expression of AT1R was detected by western blot.( <0.05), but 10 mg/L β-elemene had no such effect. β-elemene significantly reduced the amount of AT1RThe expression of AT1R protein also decreased after the treatment with β-elemene for 24 h. β-elemene

Keywords： liver cirrhosis     beta-elemene     hepatic stellate cells     angiotensin II     receptor     angiotensin     type 1    

HTML PDF Collect

expression pattern of mutations coordinated by target repression and promoter hypermethylation in acute myeloid

Frontiers of Medicine 2022, Volume 16, Issue 4,   Pages 627-636 doi: 10.1007/s11684-020-0815-4

Abstract: Runt-related transcription factor 1 (RUNX1) is an essential regulator of normal hematopoiesis.Its dysfunction, caused by either fusions or mutations, is frequently reported in acute myeloid leukemiaHowever, RUNX1 mutations have been largely under-explored compared with RUNX1 fusions mainlyin patients with RUNX1 mutations.regulated genes also contributed to dysregulation in RUNX1-mutated AML.

Keywords： RUNX1     gene mutation     acute myeloid leukemia     transcriptional repression     DNA methylation    

HTML PDF Collect

Ultraviolet-B induced expression of hypoxia-inducible factor 1α, transferrin receptor through EGFR/PI3K/AKT/DEC1 pathway

LI Yanhua, BI Zhigang

Frontiers of Medicine 2007, Volume 1, Issue 1,   Pages 79-86 doi: 10.1007/s11684-007-0016-4

Abstract: (HIF-1α) and transferrin receptor (TfR).TfR mRNA was expressed in a dose-dependent manner and reached a peak at the 8th hour in HaCat cells (UVB induced activation of EGFR in HaCat cells and EGFR regulated expression of TfR and HIF-1α.The DEC1 (-/-) Ha-Cat cells did not increase their TfR and HIF-1α expressions following UVB irradiationIn contrast, DEC1 (+/+) HaCat cells strongly enhanced TfR and HIF-1?
HTML PDF Collect

Effect of bradykinin on bradykinin-B2 receptor in rat aortic vascular smooth muscle cells and the involved

Wen YAN MD, Min FENG MD, Pei-Hua WANG MD, Dao-Wen WANG MD,

Frontiers of Medicine 2010, Volume 4, Issue 2,   Pages 225-228 doi: 10.1007/s11684-010-0003-z

Abstract: The aim of this paper is to study the effect of bradykinin (BK) on bradykinin-B2 receptor as well asthe possible involved signal transduction pathways in cultured rat aortic vascular smooth muscle cellsCells after 4–6 passages were used in the experiment.and phosphorylation of signaling molecules MAPK, Akt, and PI3K by Western blot. (1) BK markedly up-regulatedin the up-regulation of B2 receptor by BK mediation.

Keywords： bradykinin     vascular smooth muscle cells     signal transduction pathways    

HTML PDF Collect

Synthesis and properties of water-soluble 1,9-dialkyl-substituted BF

Dan Wu, Gonzalo Durán-Sampedro, Donal F. O’Shea

Frontiers of Chemical Science and Engineering 2020, Volume 14, Issue 1,   Pages 97-104 doi: 10.1007/s11705-019-1828-x

Abstract: Live cell microscopy imaging revealed efficient uptake and intracellular labelling of cells for bothNIR-active azadipyrromethene derivatives potentially useful as NIR fluorescence imaging probes for live cells

Keywords： NIR-fluorophores     live cell imaging     NIR-AZA    

HTML PDF Collect

Mutant DNA methylation regulators endow hematopoietic stem cells with the preleukemic stem cell property

Yuting Tan,Han Liu,Saijuan Chen

Frontiers of Medicine 2015, Volume 9, Issue 4,   Pages 412-420 doi: 10.1007/s11684-015-0423-x

Abstract:

Genetic mutations are considered to drive the development of acute myeloid leukemia (AML).mutations provides the first proof-of-principle investigation on the identification of preleukemic stem cellsAlthough DNMT3A mutations alone may only transform hematopoietic stem cells into pre-LSCs without causing

Keywords： preleukemic stem cell     acute myeloid leukemia     relapse     DNMT3A    

HTML PDF Collect

Gene and protein expression of proteinase-activated receptor-1, 2 in a murine model of acute graft host

Quan LI MD , Weiming LI MD , Ping ZOU MD , Jian ZHANG BM ,

Frontiers of Medicine 2009, Volume 3, Issue 3,   Pages 309-315 doi: 10.1007/s11684-009-0043-4

Abstract: PAR-1 and PAR-2 are widely expressed in a variety of cells and are found to be involved in many physiologicalHowever, little is known about the function of PAR-1, 2 in acute graft host disease (GVHD).In the present study, we first detected the expression of PAR-1, 2 protein and mRNA in a murine modelPAR-1, 2 protein expression was in accordance with the mRNA expression, as shown by Western blot.PAR-1 and PAR-2 may play an important role in the pathogenesis of acute GVHD.

Keywords： graft vs host disease     proteinase-activated receptor     murine model     hematopoietic stem cell transplantation    

HTML PDF Collect

Effects of RNA interference targeting angiotensin 1a receptor on blood pressure and cardiac hypertrophy

ZHANG Jingqun, SUN Honglei, MA Yexin, WANG Daowen

Frontiers of Medicine 2008, Volume 2, Issue 1,   Pages 19-24 doi: 10.1007/s11684-008-0005-2

Abstract: receptor (AT1a) on blood pressure and cardiac hypertrophy of rats with renovascular hypertension.Two RNAi plasmids, pAT1a-shRNA1 and pAT1a-shRNA2 each carrying a U6 promoter and an AT1a-specific shRNA-codingCompared with the control group, pAT1a-shRNA1 and pAT1a-shRNA2 groups had lowered expression of AT1 receptorreceptor in valsartan and the control groups ( > 0.05).We conclude that RNAi targeting AT1a receptor inhibits the development of renovascular hypertension and

Keywords： therapy     Sprague     administration     cardiac hypertrophy     valsartan    

HTML PDF Collect

Chimeric antigen receptor T cell targeting EGFRvIII for metastatic lung cancer therapy

Zhao Zhang, Jun Jiang, Xiaodong Wu, Mengyao Zhang, Dan Luo, Renyu Zhang, Shiyou Li, Youwen He, Huijie Bian, Zhinan Chen

Frontiers of Medicine 2019, Volume 13, Issue 1,   Pages 57-68 doi: 10.1007/s11684-019-0683-y

Abstract: In recent years, the development of tumor immunotherapy especially chimeric antigen receptor T (CAR-TEpidermal growth factor receptor variant III (EGFRvIII) is a tumor-specific mutation expressed in variousIn this study, CAR vectors were constructed and transfected into virus-packaging cells.After infection with retrovirus, CAR was expressed on more than 90% of the T cells.with an effector/target ratio of 10:1 by expressing and releasing cytokines, including perforin, granzyme

Keywords： chimeric antigen receptor T cells     epidermal growth factor receptor     lung cancer     immunotherapy     tumor immunolog    

HTML PDF Collect

Title Author Date Type Operation

Soluble triggering receptor expressed on myeloid cell-1 (sTREM-1): a potential biomarker for the diagnosis

Changlin Cao, Jingxian Gu, Jingyao Zhang

Journal Article

4-1BBL expressed by eukaryotic cells activates immune cells and suppresses the progression of murine

Hui QIU, Hui ZHANG, Zuohua FENG

Journal Article

Chimeric antigen receptor T cell therapies for acute myeloid leukemia

Bin Gu, Jianhong Chu, Depei Wu

Journal Article

Plasma soluble C-type lectin-like receptor-2 is associated with the risk of coronary artery disease

Min Fei, Li Xiang, Xichen Chai, Jingchun Jin, Tao You, Yiming Zhao, Changgeng Ruan, Yiwen Hao, Li Zhu

Journal Article

Alternative splicing of inner-ear-expressed genes

Yanfei Wang,Yueyue Liu,Hongyun Nie,Xin Ma,Zhigang Xu

Journal Article

Recent advances in myeloid-derived suppressor cell biology

Mahmoud Mohammad Yaseen, Nizar Mohammad Abuharfeil, Homa Darmani, Ammar Daoud

Journal Article

Influence of β-elemene on the secretion of angiotensin II and expression of AT1R in hepatic stellatecells

Ling YANG, Rui ZHU, Qingjing ZHU, Dan DAN, Jin YE, Keshu XU, Xiaohua HOU

Journal Article

expression pattern of mutations coordinated by target repression and promoter hypermethylation in acute myeloid

Journal Article

Ultraviolet-B induced expression of hypoxia-inducible factor 1α, transferrin receptor through EGFR/PI3K/AKT/DEC1 pathway

LI Yanhua, BI Zhigang

Journal Article

Effect of bradykinin on bradykinin-B2 receptor in rat aortic vascular smooth muscle cells and the involved

Wen YAN MD, Min FENG MD, Pei-Hua WANG MD, Dao-Wen WANG MD,

Journal Article

Synthesis and properties of water-soluble 1,9-dialkyl-substituted BF

Dan Wu, Gonzalo Durán-Sampedro, Donal F. O’Shea

Journal Article

Mutant DNA methylation regulators endow hematopoietic stem cells with the preleukemic stem cell property

Yuting Tan,Han Liu,Saijuan Chen

Journal Article

Gene and protein expression of proteinase-activated receptor-1, 2 in a murine model of acute graft host

Quan LI MD , Weiming LI MD , Ping ZOU MD , Jian ZHANG BM ,

Journal Article

Effects of RNA interference targeting angiotensin 1a receptor on blood pressure and cardiac hypertrophy

ZHANG Jingqun, SUN Honglei, MA Yexin, WANG Daowen

Journal Article

Chimeric antigen receptor T cell targeting EGFRvIII for metastatic lung cancer therapy

Zhao Zhang, Jun Jiang, Xiaodong Wu, Mengyao Zhang, Dan Luo, Renyu Zhang, Shiyou Li, Youwen He, Huijie Bian, Zhinan Chen

Journal Article